Olfactory Neuroscience | Computational Neuroscience and Neurophysiology
Department of Biological Sciences | Lehigh University
Department of Biological Sciences | Lehigh University
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Goals of the lab
Work in our lab focuses on understanding the physiological and circuit mechanisms underlying the functional and computational properties of brain neuronal networks, focusing on the olfactory system. In particular, we are interested in describing the detailed anatomical and physiological properties of cells and synapses, and then constructing models that provide insight into how these physiological properties give rise to the functional circuits that encode, transform and store information in the brain. Our goal is to use these models to understand the underlying computations that these physiological systems can be seen as implementing and to understand what happens when these mechanisms fail. I also see a goal of the lab as providing an environment in which students and postdocs can develop the technical and intellectual skills needed to become successful scientists. Neurophysiology | Computation | Behavior
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Lab News:
2021|10|18 Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb. Burton SD, Urban NN. Elife. 2021|08|03 Lateralized Decrease of Parvalbumin+ Cells in the Somatosensory Cortex of ASD Models Is Correlated with Unilateral Tactile Hypersensitivity. Deemyad T, Puig S, Papale AE, Qi H, LaRocca GM, Aravind D, LaNoce E, Urban NN.Cereb Cortex. 2021|05|21 Olfactory navigation in the real world: Simple local search strategies for turbulent environments. Hengenius JB, Connor EG, Crimaldi JP, Urban NN, Ermentrout GB.J Theor Biol. 2020|03|20 Mouse Navigation Strategies for Odor Source Localization. Liu A, Papale AE, Hengenius J, Patel K, Ermentrout B, Urban NN.Front Neurosci. 2020 Mar 20 2019|04 |01 New paper by Matt Geramita Decreased amplitude and reliability of odor-evoked responses in two mouse models of autism. Geramita MA, Wen JA, Rannals MD, Urban NN.J Neurophysiol. Nucleus accumbens feedforward inhibition circuit promotes cocaine self-administration. Yu J, Yan Y, Li KL, Wang Y, Huang YH, Urban NN, Nestler EJ, Schlüter OM, Dong Y.Proc Natl Acad Sci U S A. 2017|09|26 New Paper by First Author Annie Liu on "Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb" in eNeuro. 2017|09|21 New paper with collaborator Becky Seal on "Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb." in Nature Communications. 2017|1|5 New paper by First author Matt Geramita on "Differences in glomerular layer- mediated feed-forward inhibition onto mitral and tufted cells lead to distinct modes of intensity coding." in Journal of Neuroscience. 2017|1|5 New paper by First author Shawn Burton on "Olfactory bulb deep short-axon cells mediate widespread inhibition of tufted cell apical dendrites." in Journal of Neuroscience. 2016|10|1 Nate Glasgow joined the Urban Lab as a postdoc. 2016|10|1 Matt Geramita's manuscript "Postnatal odor exposure increases the strength of inter-glomerular lateral inhibition onto olfactory bulb tufted cells" accepted by Journal of Neuroscience. 2016|9|21 Annie Liu's manuscript "Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus" accepted by Journal of Neuroscience. 2016|7|1 Welcome to a new postdoc Matt Rannals joining the Urban lab. 2016|6|30 Manuscript on distinct circuits for mitral and tufted cell populations by Matt Geramita and Shawn Burton accepted by Elife 2016|6|8 PBS NewsHour Science Scope features part one of a series on olfactory navigation project. 2016|6|9 Matt Geramita successfully defended his thesis. Dr.Kerry Ressler was the outside examiner. Congratulations Dr. Geramita. 2016|5|30 A new graduate student Jane Huang has decided to join the lab. Welcome Jane! 2016|3|15 A new postdoc, Dr. Tara Deemyad, Joins the Urban Lab. Welcome Tara! 2016 |3| 3 Website for Olfactory navigation project is up and running. 2015|9|29 Article in Pittsburgh Post-Gazette about our odor navigation work. 2015 |9|22: Hiring postdocs for New NSF-funded project on experimental and computational approaches to olfactory navigation. Interested? Apply Here. 2015|9|21: New paper on "Establishing a Statistical Link Between Network Oscillations and Neural Synchrony" published with collaborator Rob Kass in PLoS Computational Biology. 2015|9|4: NSF Grant on "Olfactory Navigation" funded! Co-PIs include John Crimaldi (U. Colorado), Bard Ermentrout (Pitt), Lucia Jacobs (Berkeley), Kathy Nagel (NYU), Justus Verhagen (Yale), Johnathan Victor (Weill Cornell) 2015|9|3: YiYi Yu's paper "Postnatal development attunes olfactory bulb mitral cells to high frequency signaling" accepted in Journal of Neurophysiology. 2015|8|31: Postdoc candidate Tara Deemyad talks about: Retroaxonal barrage firing in NPY interneurons of the hippocampus: a role for astrocytes 2015|8|21: Shawn Burton's paper, "Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb" accepted by Journal of Neuroscience .... |
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